5-(((3S)-4-(4-(R)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Base Information

Chemical Name:5-(((3S)-4-(4-(R)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine
CAS No.:1572927-59-3
Molecular Formula:C₂₀H₂₂F₃N₅O₃S₂
Molecular Weight:501.554
Hs Code.:

Synonyms:5-(((3S)-4-(4-(R)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Suppliers and Price of 5-(((3S)-4-(4-(R)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(((3S)-4-(4-(R)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(((3S)-4-(4-(R)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

There total 14 articles about 5-(((3S)-4-(4-(R)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-22-3
tert-butyl (5-(((3S)-4-(4-(N-methyl-S-(t r ifluoromethyl)-sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1572927-58-2
5-(((3S)-4-(4-(S)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

: 1572927-59-3
5-(((3S)-4-(4-(R)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Overall yield = 45 mg;

Reference yield:

: 1450621-78-9
(3S)-1-benzyl-3-(2-propyn-1-yl)-2,5-piperazinedione

: 1572927-58-2
5-(((3S)-4-(4-(S)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

: 1572927-59-3
5-(((3S)-4-(4-(R)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

3.1: sodium t-butanolate; ruphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 20 - 100 °C / Inert atmosphere

4.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

4.2: 2 h / 80 °C

5.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; potassium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: C₁₉H₂₂N₂O₄

: 1572927-58-2
5-(((3S)-4-(4-(S)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

: 1572927-59-3
5-(((3S)-4-(4-(R)-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 80 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

4.1: sodium t-butanolate; ruphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 20 - 100 °C / Inert atmosphere

5.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

5.2: 2 h / 80 °C

6.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; potassium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;