(2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine

Base Information

Chemical Name:(2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine
CAS No.:1572928-20-1
Molecular Formula:C₂₂H₂₄F₃N₃OS
Molecular Weight:435.513
Hs Code.:

Synonyms:(2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine

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Chemical Property of (2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine

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Technology Process of (2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine

There total 10 articles about (2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1450620-25-3
(3S)-1-benzyl-3-(1-propyn-1-yl)piperazine

: 1572928-19-8
1-bromo-4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)benzene

: 1572928-20-1
(2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; ruphos; In 1,4-dioxane; at 80 - 100 ℃; Inert atmosphere;
DOI:10.1021/jm5000497

Reference yield:

: 6436-90-4
ethyl 2-(benzylamino)acetate

: 1572928-20-1
(2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 80 °C

4: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

5: sodium t-butanolate; ruphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 20 - 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1450621-78-9
(3S)-1-benzyl-3-(2-propyn-1-yl)-2,5-piperazinedione

: 1572928-20-1
(2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 80 °C

2: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

3: sodium t-butanolate; ruphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 20 - 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; potassium tert-butylate; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane;