(2S)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

Base Information

Chemical Name:(2S)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine
CAS No.:1572928-21-2
Molecular Formula:C₁₅H₁₈F₃N₃OS
Molecular Weight:345.389
Hs Code.:

Synonyms:(2S)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

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Chemical Property of (2S)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

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Technology Process of (2S)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

There total 12 articles about (2S)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-20-1
(2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine

: 1572928-21-2
(2S)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: (2S)-4-benzyl-2-(prop-1-yn-1-yl)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine; With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

With methanol; In dichloromethane; at 80 ℃; for 2h;

Reference yield:

: 1572928-19-8
1-bromo-4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)benzene

: 1572928-21-2
(2S)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium t-butanolate; ruphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 20 - 100 °C / Inert atmosphere

2.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; sodium t-butanolate; ruphos; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1450621-78-9
(3S)-1-benzyl-3-(2-propyn-1-yl)-2,5-piperazinedione

: 1572928-21-2
(2S)-1-(4-(N-methyl-S-(trifluoromethyl)sulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

3.1: sodium t-butanolate; ruphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 20 - 100 °C / Inert atmosphere

4.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

4.2: 2 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; potassium carbonate; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;