2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Base Information

Chemical Name:2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide
CAS No.:1428790-40-2
Molecular Formula:C₂₃H₂₈F₄N₄O
Molecular Weight:452.495
Hs Code.:

Synonyms:2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Suppliers and Price of 2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

There total 8 articles about 2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428790-39-9
2-(4-cyano-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

: 1428790-40-2
2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: With sodium tetrahydroborate; nickel(II) chloride hexahydrate; ethanol; for 2.25h;

Reference yield:

: 78543-07-4
ethyl 2-(3-fluoro-4-nitrophenyl)propionate

: 1428790-40-2
2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 6 h

2.1: sodium nitrite; potassium iodide; p-toluenesulfonic acid monohydrate / acetonitrile / 4.17 h / 10 - 20 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; 5-(N,N-dimethyl)amiloride hydrochloride / 15 h / 120 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

5.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / 20 °C

6.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h

6.2: 2 h

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; p-toluenesulfonic acid monohydrate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; potassium iodide; sodium hydroxide; 5-(N,N-dimethyl)amiloride hydrochloride; sodium nitrite; In tetrahydrofuran; ethanol; water; acetonitrile;

Reference yield:

: 1402585-18-5
ethyl 2-(3-fluoro-4-iodophenyl)propanoate

: 1428790-40-2
2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; 5-(N,N-dimethyl)amiloride hydrochloride / 15 h / 120 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

3.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / 20 °C

4.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h

4.2: 2 h

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel(II) chloride hexahydrate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; sodium hydroxide; 5-(N,N-dimethyl)amiloride hydrochloride; In tetrahydrofuran; ethanol; water;