Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester

Base Information

• Chemical Name: Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester
• CAS No.: 796883-91-5
• Molecular Formula: C₆₇H₈₄O₁₆P₂
• Molecular Weight: 1207.34
• Mol file: 796883-91-5.mol

Synonyms:Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester

Chemical Property of Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester

There total 6 articles about Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Octanoic acid (R)-2-{benzyloxy-[(1S,2S,3R,4S,5R,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphanyloxy}-1-octanoyloxymethyl-ethyl ester → Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester (796883-91-5)

Guidance literature:

With dihydrogen peroxide; In dichloromethane; acetonitrile; at 0 ℃; for 1h;

DOI:10.1021/ja0466098

Reference yield:

1,2-Di-O-octanoyl-sn-glycerol benzyl (N,N-diisopropylamino)phosphoramidite (163563-71-1) → Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester (796883-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 4,5-dicyanoimidazole / toluene; CH₂Cl₂

2: aq. H₂O₂ / toluene; CH₂Cl₂

With 4,5-dicyano-1H-imidazole; dihydrogen peroxide; In dichloromethane; toluene;

DOI:10.1021/jo060702s

Reference yield:

3-O-dibenzylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol (797038-13-2) → Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester (796883-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 4,5-dicyanoimidazole / toluene; CH₂Cl₂

2: aq. H₂O₂ / toluene; CH₂Cl₂

With 4,5-dicyano-1H-imidazole; dihydrogen peroxide; In dichloromethane; toluene;

DOI:10.1021/jo060702s

upstream raw materials:

1,2-Di-O-octanoyl-sn-glycerol benzyl (N,N-diisopropylamino)phosphoramidite

3-O-dibenzylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol

(+)-2,4,6-tri-O-benzyl-myo-inositol-3-phosphate

1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol