1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol

Base Information

Chemical Name:1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol
CAS No.:797038-10-9
Molecular Formula:C₅₁H₆₇O₉PSi₂
Molecular Weight:911.232
Hs Code.:

Synonyms:1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol

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Chemical Property of 1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol

Chemical Property:

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Technology Process of 1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol

There total 1 articles about 1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 474404-92-7
(+)-2,4,6-tri-O-benzyl-myo-inositol-3-phosphate

: 797038-10-9
1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 55 ℃; for 48h;
DOI:10.1021/ja0466098

Reference yield:

: 797038-10-9
1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol

: C₂₅H₄₅O₁₆P₂^(3-)*3Na⁽¹⁺⁾

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran

1.2: tetrahydrofuran / 1 h

2.1: HF*pyridine / tetrahydrofuran / 36 h

3.1: tetrazole / CH₂Cl₂; acetonitrile / 1 h

4.1: aq. H₂O₂ / CH₂Cl₂; acetonitrile / 1 h / 0 °C

5.1: H₂; aq. NaHCO₃ / Pd/C / ethanol / 16 h / 3750.3 Torr

With 1H-tetrazole; hydrogen; dihydrogen peroxide; sodium hydride; sodium hydrogencarbonate; pyridine hydrogenfluoride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/ja0466098

Reference yield:

: 797038-10-9
1,5-O-bis(t-butyldimethylsilyl)-3-O-diphenylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol

: 797038-13-2
3-O-dibenzylphosphate-2,4,6-tri-O-benzyl-D-myo-inositol

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran

1.2: tetrahydrofuran / 1 h

2.1: HF*pyridine / tetrahydrofuran / 36 h

With sodium hydride; pyridine hydrogenfluoride; In tetrahydrofuran;
DOI:10.1021/ja0466098