3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one

Base Information

Chemical Name:3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one
CAS No.:1367624-57-4
Molecular Formula:C₂₁H₂₁F₃N₄O
Molecular Weight:402.419
Hs Code.:

Synonyms:3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one

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Chemical Property of 3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one

Chemical Property:

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Technology Process of 3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one

There total 3 articles about 3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1367624-81-4
3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one hydrochloride

: 1367624-57-4
3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one

Guidance literature:: In isopropyl alcohol; at 5 ℃; for 12h;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1367624-57-4
3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3 h / Reflux

2.1: thionyl chloride / 85 °C

3.1: sodium iodide; sodium carbonate / toluene; ethanol / 20 h / Reflux

3.2: 2 h

4.1: isopropyl alcohol / 12 h / 5 °C

With thionyl chloride; sodium carbonate; sodium iodide; In ethanol; isopropyl alcohol; toluene;

Reference yield:

: 2981-86-4
3-(2-hydroxyethyl)quinazolin-4(3H)-one

: 1367624-57-4
3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 85 °C

2.1: sodium iodide; sodium carbonate / toluene; ethanol / 20 h / Reflux

2.2: 2 h

3.1: isopropyl alcohol / 12 h / 5 °C

With thionyl chloride; sodium carbonate; sodium iodide; In ethanol; isopropyl alcohol; toluene;