3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one hydrochloride

Base Information

Chemical Name:3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one hydrochloride
CAS No.:1367624-81-4
Molecular Formula:C₂₁H₂₁F₃N₄O*ClH
Molecular Weight:438.88
Hs Code.:

Synonyms:3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one hydrochloride

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Chemical Property of 3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one hydrochloride

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Technology Process of 3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one hydrochloride

There total 3 articles about 3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 2940-68-3
3-(2-Chloroethyl)-4(3H)-quinazolinone

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 1367624-81-4
3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one hydrochloride

Guidance literature:: 3-(2-Chloroethyl)-4(3H)-quinazolinone; 1-(3-Trifluoromethylphenyl)piperazine; With sodium carbonate; sodium iodide; In ethanol; toluene; for 20h; Reflux;

With hydrogenchloride; In water; isopropyl alcohol; for 2h;

Reference yield:

: 2981-86-4
3-(2-hydroxyethyl)quinazolin-4(3H)-one

: 1367624-81-4
3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 85 °C

2.1: sodium iodide; sodium carbonate / toluene; ethanol / 20 h / Reflux

2.2: 2 h

With thionyl chloride; sodium carbonate; sodium iodide; In ethanol; toluene;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1367624-81-4
3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3 h / Reflux

2.1: thionyl chloride / 85 °C

3.1: sodium iodide; sodium carbonate / toluene; ethanol / 20 h / Reflux

3.2: 2 h

With thionyl chloride; sodium carbonate; sodium iodide; In ethanol; toluene;