Sabizabulin

Base Information

Chemical Name:Sabizabulin
CAS No.:1332881-26-1
Molecular Formula:C₂₁H₁₉N₃O₄
Molecular Weight:377.4
Hs Code.:
European Community (EC) Number:889-539-8
UNII:37L1JX37J5
Wikipedia:Sabizabulin
NCI Thesaurus Code:C158517
ChEMBL ID:CHEMBL2163631

Synonyms:(2-(1H-indol-3-yl)-1H-imidazol-5-yl)-(3,4,5-trimethoxyphenyl)methanone;methanone, (2-(1H-indol-3-yl)-1H-imidazol-5-yl)(3,4,5-trimethoxyphenyl)-;sabizabulin;VERU-111

Suppliers and Price of Sabizabulin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
VERU-111
100mg
$ 2850.00

ChemScene
VERU-111
50mg
$ 1800.00

ChemScene
VERU-111
25mg
$ 1150.00

ChemScene
VERU-111
10mg
$ 600.00

ChemScene
VERU-111
5mg
$ 380.00

Total 4 raw suppliers

Chemical Property of Sabizabulin

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:377.13755610
Heavy Atom Count:28
Complexity:534

Purity/Quality:

98% ^*data from raw suppliers

VERU-111 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C(=O)C2=CN=C(N2)C3=CNC4=CC=CC=C43
Recent ClinicalTrials:To Evaluate Safety and Tolerability of VERU-111 in Men With Advanced Metastatic Castration Resistant Prostate Cancer
Recent EU Clinical Trials:Phase 3, Randomized, Placebo-Controlled, Efficacy and Safety Study of VERU-111 for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Patients at High Risk for Acute Respiratory Distress Syndrome (ARDS)

Technology Process of Sabizabulin

There total 5 articles about Sabizabulin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1332881-55-6
(1-(phenylsulfonyl)-2-(1-(phenylsulfonyl)-1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

: 1332881-26-1
(2-(1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: With water; sodium hydroxide; In ethanol; Darkness; Reflux;

Reference yield:

: 80360-20-9
1-(phenylsulfonyl)indole-3-carbaldehyde

: 1332881-26-1
(2-(1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium hydroxide / ethanol; water / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

3.2: -78 °C

4.1: sodium hydroxide / ethanol; water / Reflux; Darkness

With ammonium hydroxide; tert.-butyl lithium; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; water; mineral oil; pentane;

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 1332881-26-1
(2-(1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; acetone / 0.5 h / 20 °C

2.1: ammonium hydroxide / ethanol; water / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

4.2: -78 °C

5.1: sodium hydroxide / ethanol; water / Reflux; Darkness

With ammonium hydroxide; tert.-butyl lithium; sodium hydride; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; water; acetone; mineral oil; pentane;