Eleclazine (hydrochloride)

Base Information

• Chemical Name: Eleclazine (hydrochloride)
• CAS No.: 1448754-43-5
• Molecular Formula: C₂₁H₁₆F₃N₃O₃*ClH
• Molecular Weight: 451.832
• Mol file: 1448754-43-5.mol

Synonyms:4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one HCl salt

Chemical Property of Eleclazine (hydrochloride)

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

Eleclazinehydrochloride >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Eleclazine (hydrochloride)

There total 5 articles about Eleclazine (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (1443211-72-0) → 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one HCl salt (1448754-43-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield:

7-bromo-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (5755-05-5) → 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one HCl salt (1448754-43-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 20 - 95 °C

1.2: 4 h / 20 °C

2.1: potassium carbonate / toluene; isopropyl alcohol; water / 0.17 h / Inert atmosphere

2.2: 2 h / 85 °C

3.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; potassium carbonate; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

6-bromochroman-4-one (49660-57-3) → 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one HCl salt (1448754-43-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanesulfonic acid; sodium azide / 16.75 h / 20 °C / Cooling with ice

2.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 20 - 95 °C

2.2: 4 h / 20 °C

3.1: potassium carbonate / toluene; isopropyl alcohol; water / 0.17 h / Inert atmosphere

3.2: 2 h / 85 °C

4.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; sodium azide; methanesulfonic acid; potassium carbonate; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

upstream raw materials:

7-bromo-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

6-bromochroman-4-one

4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

Refernces

• 1、 -. "COMBINATION THERAPIES USING LATE SODIUM ION CHANNEL BLOCKERS AND POTASSIUM ION CHANNEL BLOCKERS". . . Retrieved 2013/08/15.