5755-05-5Relevant articles and documents
Discovery of 3,4-Dihydrobenzo[ f][1,4]oxazepin-5(2 H)-one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects
Li, Yueshan,Zhang, Liting,Yang, Ruicheng,Qiao, Zeen,Wu, Ming,Huang, Chong,Tian, Chenyu,Luo, Xinling,Yang, Wei,Zhang, Yun,Li, Linli,Yang, Shengyong
supporting information, p. 1786 - 1807 (2022/01/20)
The Traf2- and Nck-interacting protein kinase (TNIK) is a downstream signal protein of the Wnt/β-catenin pathway and has been thought of as a potential target for the treatment of colorectal cancer (CRC) that is often associated with dysregulation of Wnt/
Deuterium-Substituted Oxazepin Compounds
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Paragraph 0309; 0310, (2018/03/24)
Described are deuterium-substituted oxazepin compounds of structural Formula I, which are inhibitors/blockers of the late sodium current. Also described are pharmaceutical compositions comprising the deuterium-substituted oxazepin compounds, and methods of use thereof.
PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS
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Paragraph 0369; 0376; 0377, (2015/09/22)
The present disclosure provides processes for the preparation of a compound of formula: which is a selective late sodium current inhibitor. The disclosure also provides compounds that are synthetic intermediates.