1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide
CAS No.:1558036-85-3
Molecular Formula:C₂₄H₂₅N₅O₃
Molecular Weight:431.494
Hs Code.:

Synonyms:1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Suppliers and Price of 1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 8 raw suppliers

Chemical Property of 1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

There total 14 articles about 1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (R)-5-amino-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide hydrochloride

: 814-68-6,25189-84-8
acryloyl chloride

: 1558036-85-3
1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -15 - 0 ℃; for 0.0833333h;

Reference yield: 35.0%

: 1558038-42-8
(R)-5-amino-3-(4-phenoxyphenyl)-1-piperidin-3-yl-1H-pyrazole-4-carboxylic acid amide

: 79-10-7
acrylic acid

: 1558036-85-3
1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.25h;
DOI:10.1021/acsmedchemlett.8b00461

Reference yield:

: 330792-69-3
2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile

: 1558036-85-3
1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / ethanol / 16 h / 55 °C

2: hydrogen; palladium 10% on activated carbon / 2-methyltetrahydrofuran / 16 h / 65 °C

3: sodium hydroxide / ethanol / 0.5 h / 150 °C / Sealed tube

4: triethylamine / ethanol

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C

With palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 2-methyltetrahydrofuran; ethanol; N,N-dimethyl-formamide;