(2S,4R)-4-(4-bromo-3-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:(2S,4R)-4-(4-bromo-3-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylic acid dimethyl ester
CAS No.:612067-14-8
Molecular Formula:C₁₆H₁₈BrNO₅
Molecular Weight:384.227
Hs Code.:

Synonyms:(2S,4R)-4-(4-bromo-3-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylic acid dimethyl ester

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Chemical Property of (2S,4R)-4-(4-bromo-3-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylic acid dimethyl ester

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Technology Process of (2S,4R)-4-(4-bromo-3-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylic acid dimethyl ester

There total 3 articles about (2S,4R)-4-(4-bromo-3-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27561-51-9
1-bromo-4-(bromomethyl)-2-methylbenzene

: 158554-84-8
dimethyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate

: 612067-14-8
(2S,4R)-4-(4-bromo-3-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: dimethyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

1-bromo-4-(bromomethyl)-2-methylbenzene; In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield:

: 7697-28-1
4-bromo-3-methylbenzoic acid

: 612067-14-8
(2S,4R)-4-(4-bromo-3-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / lithium aluminium hydride / diethyl ether / 2 h / 20 °C

2.1: phosphorus tribromide / diethyl ether / 1 h / Heating

3.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

3.2: tetrahydrofuran / 2 h / -78 °C

With lithium aluminium tetrahydride; phosphorus tribromide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether;

Reference yield:

: 149104-89-2
4-bromo-3-methylbenzylalcohol

: 612067-14-8
(2S,4R)-4-(4-bromo-3-methylbenzyl)-5-oxopyrrolidine-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: phosphorus tribromide / diethyl ether / 1 h / Heating

2.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 2 h / -78 °C

With phosphorus tribromide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether;