27561-51-9Relevant academic research and scientific papers
Scalable synthesis of [8]cycloparaphenyleneacetylene carbon nanohoop using alkyne metathesis
Bruns, Carson J.,Fronczek, Frank R.,Herman, Robert J.,Kwon, Hyejin,Lee, Semin,Thompson, Richard R.,Zhou, Xin
, p. 10887 - 10890 (2021/10/22)
Large scale synthesis of cycloparaphenyleneacetylenes has been challenging due to low macrocyclization yields and harsh aromatization methods that often decompose strained alkynes. Herein, acis-stilbene-based building block is subjected to alkyne metathes
COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY
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, (2017/03/14)
This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL- cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small organic compound ligands that can raise LDL levels.
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors
Pensa, Anthony V.,Cinelli, Maris A.,Li, Huiying,Chreifi, Georges,Mukherjee, Paramita,Roman, Linda J.,Martásek, Pavel,Poulos, Thomas L.,Silverman, Richard B.
, p. 7146 - 7165 (2017/09/07)
Neuronal nitric oxide synthase (nNOS) is a target for development of antineurodegenerative agents. Most nNOS inhibitors mimic l-arginine and have poor bioavailability. 2-Aminoquinolines showed promise as bioavailable nNOS inhibitors but suffered from low
COMPOSITION AND METHODS OF USE OF TETRAHYDROISOQUINOLINE SMALL MOLECULES TO BIND AND MODULATE PCSK9 PROTEIN ACTIVITY
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Page/Page column 37; 38, (2017/03/14)
This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds
BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS
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Paragraph 0164, (2015/04/15)
Compounds, pharmaceutical formulations, and methods of treating inflammatory conditions are disclosed.(F)
Synthesis of end-group functionalized P3HT: General protocol for P3HT/nanoparticle hybrids
Monnaie, Frederic,Brullot, Ward,Verbiest, Thierry,De Winter, Julien,Gerbaux, Pascal,Smeets, Alfons,Koeckelberghs, Guy
, p. 8500 - 8508 (2013/12/04)
Poly(3-hexylthiophene)s were synthesized with phosphonic ester, pyridine, thiol, and phenol end-groups using functionalized air-stable Ni initiators. The protected thiol- and phenol-functionalized P3HTs were converted into thiol and phenol P3HTs by quanti
PYRROLIDINE GPR40 MODULATORS
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, (2011/04/24)
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECE TOR TRPVL RELATED DISORDERS
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Page/Page column 57-58, (2008/06/13)
The claimed invention provides benzimidazole derivatives antagonists of VRl, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds of Formula I may be used in the treatment of osteoarthritis,
BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS
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, (2008/06/13)
A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R1: -COR9 (wherein R9: alkyl, optionally substituted alkoxy or optionally substituted amino); R2: H, OH, alkoxy, optionally substituted amino, etc.; R3: H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno, etc.; R4 and R5: H, optionally substituted alkyl, halogeno, etc.; R6 and R7: H, alkyl; R8: -X2R10 [wherein R10: -COR11 (wherein R11 : OH, optionally substituted alkoxy, optionally substituted amino, etc.), -SO2R12 (wherein R12: optionally substituted alkyl, optionally substituted amino, etc.), tetrazol-5-yl, etc.; X2: single bond, optionally substituted alkylene, etc.]; X1: -NH-, -O-, -S-, etc.; Y1: optionally substituted phenyl, optionally substituted 5- to 6-membered aromatic heterocyclyl; Y2: optionally substituted aryl, optionally substituted heterocyclyl, etc.] and the like is provided.
