(+/-)-t-butyl-3-[(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate

Base Information

Chemical Name:(+/-)-t-butyl-3-[(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate
CAS No.:1235977-25-9
Molecular Formula:C₂₇H₂₆N₄O₇
Molecular Weight:518.526
Hs Code.:

Synonyms:(+/-)-t-butyl-3-[(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate

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Chemical Property of (+/-)-t-butyl-3-[(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate

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Technology Process of (+/-)-t-butyl-3-[(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate

There total 6 articles about (+/-)-t-butyl-3-[(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1195785-11-5
N-Boc-4-nitroindole-3-carboxaldehyde

: 59552-69-1
(+/-)-1,4-diacetyl-3-benzylpiperazine-2,5-dione

: 1235977-25-9
(+/-)-t-butyl-3-[(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; for 18h; Inert atmosphere; Darkness;
DOI:10.1071/CH10006

Reference yield:

: 30166-29-1,30166-30-4,41808-11-1
1-acetyl-3-[(Z)-benzylidene]-2,5-piperazinedione

: 1235977-25-9
(+/-)-t-butyl-3-[(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen; acetic acid / tetrahydrofuran / 20 °C / 760.05 Torr

2: pyridine; dmap / dichloromethane / 18 h / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 18 h / Inert atmosphere; Darkness

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1071/CH10006

Reference yield:

: 1235977-29-3
(+/-)-1-acetyl-6-benzylpiperazine-2,5-dione

: 1235977-25-9
(+/-)-t-butyl-3-[(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; dmap / dichloromethane / 18 h / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / Inert atmosphere; Darkness

With pyridine; dmap; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1071/CH10006