3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionaldehyde

Base Information

Chemical Name:3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionaldehyde
CAS No.:141863-27-6
Molecular Formula:C₃₄H₃₅ClN₂O₂S
Molecular Weight:571.183
Hs Code.:

Synonyms:3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionaldehyde

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Chemical Property of 3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionaldehyde

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Technology Process of 3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionaldehyde

There total 2 articles about 3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141863-26-5
3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol

: 141863-27-6
3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionaldehyde

Guidance literature:: With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; for 1h; -78 deg C -> rt;
DOI:10.1016/S0960-894X(96)00271-5

Reference yield:

: 136668-42-3
quiflapon

: 141863-27-6
3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: BH₃*DMS / tetrahydrofuran / 12 h

2: (COCl)2 / dimethylsulfoxide; CH₂Cl₂ / 1 h / -78 deg C -> rt

With oxalyl dichloride; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0960-894X(96)00271-5