Quiflapon

Base Information

• Chemical Name: Quiflapon
• CAS No.: 136668-42-3
• Molecular Formula: C34H35 Cl N2 O3 S
• Molecular Weight: 587.182
• Mol file: 136668-42-3.mol

Synonyms:MK0591; Quiflapon

Chemical Property of Quiflapon

Chemical Property:

• Vapor Pressure: 1.03E-23mmHg at 25°C
• Boiling Point: 751.3°Cat760mmHg
• PKA: 4.70±0.10(Predicted)
• Flash Point: 408.2°C
• PSA: 89.65000
• Density: 1.21g/cm³
• LogP: 9.01410
• Solubility.: Soluble in DMSO

Purity/Quality:

98%Min ^*data from raw suppliers

3-(3-(tert-Butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Anti-asthmatic; suppressant (inflammatory bowel disease).

Technology Process of Quiflapon

There total 5 articles about Quiflapon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ quiflapon (136668-42-3)

Guidance literature:

Reference yield:

1-(4-chlorophenylmethyl)-1-(4-(quinolin-2-ylmethoxy)phenyl)hydrazine (133166-04-8) → quiflapon (136668-42-3)

Guidance literature:

Reference yield:

methyl 3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionate (136694-18-3) → quiflapon (136668-42-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; for 3h; Heating;

DOI:10.1016/S0960-894X(99)00399-6

upstream raw materials:

methyl 3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionate

quinolin-2-ylmethylbromide

methyl 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-hydroxyindol-2-yl]-2,2-dimethylpropionate

1-(4-chlorophenylmethyl)-1-(4-(quinolin-2-ylmethoxy)phenyl)hydrazine

Downstream raw materials:

3-[3-(4-chlorobenzyl)-6-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid

3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropionaldehyde

3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol

Refernces

• 1、 -. "(Quinolin-2-ylmethoxy)indole/cyclodextrin complex". . . Retrieved 2008/06/13.
• 2、 -. "Amorphous (quinolin-2-ylmethoxy)indole compounds which have useful pharmaceutical utility". . . Retrieved 2008/06/13.