3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol

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Chemical Name:3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol
CAS No.:141863-26-5
Molecular Formula:C₃₄H₃₇ClN₂O₂S
Molecular Weight:573.199
Hs Code.:

Synonyms:3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol

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Chemical Property of 3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol

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Technology Process of 3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol

There total 7 articles about 3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 189239-02-9
3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester

: 141863-26-5
3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol

Guidance literature:: With sodium tetrahydroborate; calcium chloride; In tetrahydrofuran; ethanol; a) 0 deg C, 2 h, b) RT, 14 h;
DOI:10.1016/S0968-0896(96)00265-9

Reference yield:

: 136668-42-3
quiflapon

: 141863-26-5
3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; for 12h;
DOI:10.1016/S0960-894X(96)00271-5

Reference yield:

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 141863-26-5
3-[3-(1,1-dimethylethylthio)-5-(quinolin-2-ylmethoxy)-1-(4-chlorophenylmethyl)indol-2-yl]-2,2-dimethylpropanol

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / diisopropylamine, tetrabutylammonium bromide / CH₂Cl₂ / 48 h / Ambient temperature

2: 50 percent / acetic acid / toluene / 96 h / Ambient temperature

3: 70 percent / AlCl₃, t-BuSH / CH₂Cl₂ / a) 0 deg C, 10 min, b) RT, 3 h

4: 84 percent / K₂CO₃ / dimethylformamide / a) 60 deg C, 3 h, b) RT, 15 h

5: 99 percent / NaBH₄, CaCl₂ / ethanol; tetrahydrofuran / a) 0 deg C, 2 h, b) RT, 14 h

With sodium tetrahydroborate; aluminium trichloride; tetrabutylammomium bromide; potassium carbonate; 2-methylpropan-2-thiol; acetic acid; diisopropylamine; calcium chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0968-0896(96)00265-9