10-(3-chlorobenzyl)-N-(3-(cyclohexyl(methyl)amino)-propyl)-11-oxo-10,11 dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide

Base Information

Chemical Name:10-(3-chlorobenzyl)-N-(3-(cyclohexyl(methyl)amino)-propyl)-11-oxo-10,11 dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide
CAS No.:1319194-05-2
Molecular Formula:C₃₁H₃₄ClN₃O₂S
Molecular Weight:548.149
Hs Code.:

Synonyms:10-(3-chlorobenzyl)-N-(3-(cyclohexyl(methyl)amino)-propyl)-11-oxo-10,11 dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide

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Chemical Property of 10-(3-chlorobenzyl)-N-(3-(cyclohexyl(methyl)amino)-propyl)-11-oxo-10,11 dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide

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Technology Process of 10-(3-chlorobenzyl)-N-(3-(cyclohexyl(methyl)amino)-propyl)-11-oxo-10,11 dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide

There total 11 articles about 10-(3-chlorobenzyl)-N-(3-(cyclohexyl(methyl)amino)-propyl)-11-oxo-10,11 dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 897772-23-5
C₂₁H₁₄ClNO₃S

: 26735-20-6
N¹-cyclohexyl-N¹-methylpropane-1,3-diamine

: 1319194-05-2
10-(3-chlorobenzyl)-N-(3-(cyclohexyl(methyl)amino)-propyl)-11-oxo-10,11 dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2011.05.028

Reference yield:

: 440627-10-1
3-amino-4-(2-carboxy-phenylsulfanyl)-benzoic acid

: 1319194-05-2
10-(3-chlorobenzyl)-N-(3-(cyclohexyl(methyl)amino)-propyl)-11-oxo-10,11 dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 29 h / -20 - 20 °C

2.1: dmap / N,N-dimethyl-formamide / 13 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / -20 - 5 °C / Inert atmosphere

3.2: 19.5 h / -20 - 20 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; water / 37 h / 0 - 20 °C

4.2: pH 7

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With dmap; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.028

Reference yield:

: 1319194-14-3
methyl 3-amino-4-((2-(methoxycarbonyl)phenyl)thio)-benzoate

: 1319194-05-2
10-(3-chlorobenzyl)-N-(3-(cyclohexyl(methyl)amino)-propyl)-11-oxo-10,11 dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 37 h / 0 - 20 °C

1.2: pH 4

2.1: N,N-dimethyl-formamide / 29 h / -20 - 20 °C

3.1: dmap / N,N-dimethyl-formamide / 13 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / -20 - 5 °C / Inert atmosphere

4.2: 19.5 h / -20 - 20 °C / Inert atmosphere

5.1: lithium hydroxide / tetrahydrofuran; water / 37 h / 0 - 20 °C

5.2: pH 7

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With dmap; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.028