26735-20-6 Usage
Uses
Used in Oncology:
PACMA is utilized as a chemosensitizer in cancer treatment for its ability to inhibit the activity of the enzyme glutathione S-transferase P1-1. This enzyme is overexpressed in cancer cells and contributes to their resistance to chemotherapy. By targeting this enzyme, PACMA enhances the effectiveness of chemotherapeutic agents and combats drug resistance in cancer cells.
Used in Neurology:
In the field of neurology, PACMA has been investigated as a potential treatment for Parkinson's disease. Its neuroprotective properties make it a candidate for further research into its capacity to protect and preserve neuronal function, potentially slowing the progression of neurodegenerative diseases like Parkinson's.
Check Digit Verification of cas no
The CAS Registry Mumber 26735-20-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,7,3 and 5 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 26735-20:
(7*2)+(6*6)+(5*7)+(4*3)+(3*5)+(2*2)+(1*0)=116
116 % 10 = 6
So 26735-20-6 is a valid CAS Registry Number.
26735-20-6Relevant academic research and scientific papers
2-PHENYL-5-AMINO-1,3,4-OXADIAZOLES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
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Page/Page column 29, (2008/06/13)
The present invention relates to novel oxadiazole derivatives of formula (1) having pharmacological activity, processes for their preparation, compositions containing them and their use in the treatment of neurological, psychiatric disorders and gastrointestinal disorders through modulation of the nicotinic α7 receptor formula (I).
