methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate

Base Information

• Chemical Name: methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate
• CAS No.: 897771-13-0
• Molecular Formula: C₁₅H₁₁NO₃S
• Molecular Weight: 285.323
• Mol file: 897771-13-0.mol

Synonyms:methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate

Chemical Property of methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate

There total 1 articles about methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + C17H11N3O2S → methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate (897771-13-0) + 11-oxo-10,11-dihydro-dibenzo [b,f][1,4]thiazepine-8-carboxylic acid (440627-14-5)

Guidance literature:

With dmap; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 13h;

DOI:10.1016/j.bmc.2011.05.028

Reference yield: 79.0%

methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate (897771-13-0) + 1-bromomethyl-3-chlorobenzene (766-80-3) → methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate (895795-22-9)

Guidance literature:

methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at -20 - 5 ℃; Inert atmosphere;

1-bromomethyl-3-chlorobenzene; In N,N-dimethyl-formamide; at -20 - 20 ℃; for 19.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2011.05.028

Reference yield:

methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate (897771-13-0) → C21H14ClNO3S (897772-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / -20 - 5 °C / Inert atmosphere

1.2: 19.5 h / -20 - 20 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 37 h / 0 - 20 °C

2.2: pH 7

With sodium hydride; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.05.028

upstream raw materials:

methanol

Downstream raw materials:

C₂₁H₁₄ClNO₃S

10-(3-chlorobenzyl)-N-(3-(cyclohexyl(methyl)amino)-propyl)-11-oxo-10,11 dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide

methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate