1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone

Base Information

• Chemical Name: 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone
• CAS No.: 180740-55-0
• Molecular Formula: C₂₀H₃₄O₂Si
• Molecular Weight: 334.574

Synonyms:1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone

Chemical Property of 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone

Chemical Property:

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Technology Process of 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone

There total 3 articles about 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol (180740-54-9) → 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone (180740-55-0)

Guidance literature:

With Celite; pyridinium chlorochromate; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jo971409i

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone (180740-55-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaH / tetrahydrofuran / 2.5 h

2: 98 percent / PCC, Celite / CH₂Cl₂ / 3 h / Ambient temperature

With Celite; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo971409i

Reference yield:

1-[3-tert-butyl-5-(1-hydroxyethyl)phenyl]ethanol (180740-53-8) → 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone (180740-55-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaH / tetrahydrofuran / 2.5 h

2: 98 percent / PCC, Celite / CH₂Cl₂ / 3 h / Ambient temperature

With Celite; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo971409i

upstream raw materials:

1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol

tert-butyldimethylsilyl chloride

1-[3-tert-butyl-5-(1-hydroxyethyl)phenyl]ethanol

Downstream raw materials:

1-[3-tert-butyl-5-(1-hydroxyethyl)phenyl]-2-methylpropionaldehyde

LGD₁₅₅₀

ethyl (2E, 4E, 6E)-7-(3,5-di-t-butylphenyl)-3-methylocta-2,4,6-trienoate

2-[3-tert-Butyl-5-(1-hydroxy-ethyl)-phenyl]-2-methyl-propan-1-ol

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