1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol

Base Information

Chemical Name:1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol
CAS No.:180740-54-9
Molecular Formula:C₂₀H₃₆O₂Si
Molecular Weight:336.59
Hs Code.:

Synonyms:1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol

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Chemical Property of 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol

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Technology Process of 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol

There total 1 articles about 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 180740-53-8
1-[3-tert-butyl-5-(1-hydroxyethyl)phenyl]ethanol

: 180740-54-9
1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 2.5h;
DOI:10.1021/jo971409i

Reference yield: 98.0%

: 180740-54-9
1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol

: 180740-55-0
1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone

Guidance literature:: With Celite; pyridinium chlorochromate; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jo971409i

Reference yield:

: 180740-54-9
1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol

: 180740-63-0
(2E,4E,6E)-7-[3-tert-Butyl-5-(1,1-dimethyl-2-oxo-ethyl)-phenyl]-3-methyl-octa-2,4,6-trienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 98 percent / PCC, Celite / CH₂Cl₂ / 3 h / Ambient temperature

3: 1.76 g / NaBH₄ / methanol / 0.5 h / Ambient temperature

4: MnO₂ / CH₂Cl₂ / 4 h

5: 78 percent / imidazole, DMF / CH₂Cl₂ / Ambient temperature

6: 63 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h

7: 75 percent / DIBAL / CH₂Cl₂ / 1 h / -78 °C

8: 86 percent / n-BuLi / 1.) THF, hexane, DMPU, 0 deg C, 20 min, 2.) THF, -78 deg C, 60 min

9: TBAF / tetrahydrofuran / 12 h / Ambient temperature

10: PCC, Celite / CH₂Cl₂ / 3 h / Ambient temperature

With 1H-imidazole; manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; Celite; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; N,N-dimethyl-formamide; pyridinium chlorochromate; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo971409i