α-(trimethylsiloxy)-1-neopentyl phenyl ketone

Base Information

• Chemical Name: α-(trimethylsiloxy)-1-neopentyl phenyl ketone
• CAS No.: 56346-01-1
• Molecular Formula: C₁₅H₂₄O₂Si
• Molecular Weight: 264.44
• Mol file: 56346-01-1.mol

Synonyms:α-(trimethylsiloxy)-1-neopentyl phenyl ketone

Chemical Property of α-(trimethylsiloxy)-1-neopentyl phenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of α-(trimethylsiloxy)-1-neopentyl phenyl ketone

There total 3 articles about α-(trimethylsiloxy)-1-neopentyl phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

phenyl(trimethylsiloxy)acetonitrile (25438-37-3) + pivalaldehyde (630-19-3) → α-(trimethylsiloxy)-1-neopentyl phenyl ketone (56346-01-1)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; for 2h;

DOI:10.1039/a709114a

Reference yield:

diethyl 1-phenyl-1-(trimethylsiloxy)methanephosphonate (31675-43-1) + pivalaldehyde (630-19-3) → α-(trimethylsiloxy)-1-neopentyl phenyl ketone (56346-01-1)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1. THF, cyclohexane, -78 deg C, 30 min, 2a. 30 min, 2b. RT, overnight;

DOI:10.1021/jo00007a048

Reference yield:

→ α-(trimethylsiloxy)-1-neopentyl phenyl ketone (56346-01-1)

Guidance literature:

upstream raw materials:

diethyl 1-phenyl-1-(trimethylsiloxy)methanephosphonate

pivalaldehyde

phenyl(trimethylsiloxy)acetonitrile

Downstream raw materials:

α-hydroxy-1-neopentyl phenyl ketone