Technology Process of 20(R)-20-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnane-21,14β-lactone
There total 8 articles about 20(R)-20-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnane-21,14β-lactone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N,N-dimethylaniline / diethyl ether / 0.25 h
2: 45 percent / cupric chloride dihydrate, lithium chloride / dimethylformamide / 3 h / 100 °C
3: 1.) DIBAH / 1.) toluene; 2.) toluene, methanol, 15 min.
With
diisobutylaluminium hydride; N,N-dimethyl-aniline; lithium chloride; copper dichloride;
In
diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80082-X
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 60 percent / selenium dioxide / H2O; dioxane / 6 h / Heating
2: 92 percent / 5percent palladium-on-carbon / tetrahydrofuran
3: triethylamine, hydrazine hydrate / ethanol / 1.5 h / Heating
4: iodine, triethylamine / tetrahydrofuran
5: 90 percent / sodium / ethanol; H2O / Heating
6: N,N-dimethylaniline / diethyl ether / 0.25 h
7: 45 percent / cupric chloride dihydrate, lithium chloride / dimethylformamide / 3 h / 100 °C
8: 1.) DIBAH / 1.) toluene; 2.) toluene, methanol, 15 min.
With
palladium on activated charcoal; selenium(IV) oxide; iodine; sodium; diisobutylaluminium hydride; hydrazine hydrate; N,N-dimethyl-aniline; triethylamine; lithium chloride; copper dichloride;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80082-X
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine, hydrazine hydrate / ethanol / 1.5 h / Heating
2: iodine, triethylamine / tetrahydrofuran
3: 90 percent / sodium / ethanol; H2O / Heating
4: N,N-dimethylaniline / diethyl ether / 0.25 h
5: 45 percent / cupric chloride dihydrate, lithium chloride / dimethylformamide / 3 h / 100 °C
6: 1.) DIBAH / 1.) toluene; 2.) toluene, methanol, 15 min.
With
iodine; sodium; diisobutylaluminium hydride; hydrazine hydrate; N,N-dimethyl-aniline; triethylamine; lithium chloride; copper dichloride;
In
tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80082-X
