14β,21-epoxy-20ξ-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnan-21ξ-ol

Base Information

Chemical Name:14β,21-epoxy-20ξ-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnan-21ξ-ol
CAS No.:123849-43-4
Molecular Formula:C₃₁H₄₄O₅S
Molecular Weight:528.753
Hs Code.:

Synonyms:14β,21-epoxy-20ξ-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnan-21ξ-ol

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Chemical Property of 14β,21-epoxy-20ξ-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnan-21ξ-ol

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Technology Process of 14β,21-epoxy-20ξ-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnan-21ξ-ol

There total 10 articles about 14β,21-epoxy-20ξ-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnan-21ξ-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 123849-42-3
20(R)-20-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnane-21,14β-lactone

: 123849-43-4
14β,21-epoxy-20ξ-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnan-21ξ-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.166667h;
DOI:10.1016/S0040-4020(01)80082-X

Reference yield:

: 123849-39-8
3β-methoxy-5α,14β-androst-16-en-14-ol

: 123849-43-4
14β,21-epoxy-20ξ-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnan-21ξ-ol

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethylaniline / diethyl ether / 0.25 h

2: 45 percent / cupric chloride dihydrate, lithium chloride / dimethylformamide / 3 h / 100 °C

3: 1.) DIBAH / 1.) toluene; 2.) toluene, methanol, 15 min.

4: 78 percent / DIBAH / toluene / 0.17 h / -78 °C

With diisobutylaluminium hydride; N,N-dimethyl-aniline; lithium chloride; copper dichloride; In diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)80082-X

Reference yield:

: 108-98-5
thiophenol

: 123849-43-4
14β,21-epoxy-20ξ-carboethoxy-3β-methoxy-16α-thiophenyl-5α-pregnan-21ξ-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DIBAH / 1.) toluene; 2.) toluene, methanol, 15 min.

2: 78 percent / DIBAH / toluene / 0.17 h / -78 °C

With diisobutylaluminium hydride; In toluene;
DOI:10.1016/S0040-4020(01)80082-X