tert-butyl (4-chlorophenyl)sulfonyl(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

Base Information

Chemical Name:tert-butyl (4-chlorophenyl)sulfonyl(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate
CAS No.:1333144-75-4
Molecular Formula:C₃₀H₃₈ClNO₆S
Molecular Weight:576.154
Hs Code.:

Synonyms:tert-butyl (4-chlorophenyl)sulfonyl(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

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Chemical Property of tert-butyl (4-chlorophenyl)sulfonyl(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

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Technology Process of tert-butyl (4-chlorophenyl)sulfonyl(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

There total 7 articles about tert-butyl (4-chlorophenyl)sulfonyl(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1333144-68-5
5-(3-(2-hydroxyethyl)benzyl)-3-isobutoxy-2-methylcyclopent-2-enone

: 133033-79-1
N-(tert-butoxycarbonyl)-4-chlorobenzenesulfonamide

: 1333144-75-4
tert-butyl (4-chlorophenyl)sulfonyl(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm200980u

Reference yield:

: 1333144-57-2
3-(2-((triisopropylsilyl)oxy)ethyl)benzaldehyde

: 1333144-75-4
tert-butyl (4-chlorophenyl)sulfonyl(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / Reflux

2.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 2 h / 0 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / -78 °C

3.2: -78 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; iodine; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; hexane; water; toluene; acetonitrile; 5.1: Mitsunobu reaction;
DOI:10.1021/jm200980u

Reference yield:

: 1333144-58-3
3-(2-((triisopropylsilyl)oxy)ethyl)phenylmethanol

: 1333144-75-4
tert-butyl (4-chlorophenyl)sulfonyl(3-((4-isobutoxy-3-methyl-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 2 h / 0 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / -78 °C

2.2: -78 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; iodine; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; hexane; toluene; acetonitrile; 4.1: Mitsunobu reaction;
DOI:10.1021/jm200980u