2-[2,3-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-phenoxy]-tetrahydro-pyran

Base Information

Chemical Name:2-[2,3-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-phenoxy]-tetrahydro-pyran
CAS No.:95695-11-7
Molecular Formula:C₂₆H₄₈O₅Si₂
Molecular Weight:496.835
Hs Code.:

Synonyms:2-[2,3-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-phenoxy]-tetrahydro-pyran

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Chemical Property of 2-[2,3-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-phenoxy]-tetrahydro-pyran

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Technology Process of 2-[2,3-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-phenoxy]-tetrahydro-pyran

There total 4 articles about 2-[2,3-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-phenoxy]-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 95695-10-6
[2-Hydroxymethyl-4-methoxy-6-(tetrahydro-pyran-2-yloxy)-phenyl]-methanol

: 95695-11-7
2-[2,3-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-phenoxy]-tetrahydro-pyran

Guidance literature:: With 1H-imidazole; for 24h; Ambient temperature;
DOI:10.1021/ja00295a025

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 95695-11-7
2-[2,3-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-phenoxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium tosylate

2: LiBH₄ / diethyl ether

With lithium borohydride; pyridinium p-toluenesulfonate; In diethyl ether;
DOI:10.1021/ja00229a041

Reference yield:

: 24953-74-0
dimethyl 3-hydroxy-5-methoxyphthalate

: 95695-11-7
2-[2,3-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-phenoxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / p-toluenesulfonic acid / CH₂Cl₂ / 12 h / 0 °C

2: 99 percent / lithium aluminum hydride / diethyl ether; benzene / 2 h / 25 °C

3: 93 percent / imidazole / 24 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; benzene;
DOI:10.1021/ja00295a025