(E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate

Base Information

• Chemical Name: (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate
• CAS No.: 1334209-45-8
• Molecular Formula: C₂₁H₂₅NO₄S
• Molecular Weight: 387.5
• Mol file: 1334209-45-8.mol

Synonyms:(E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate

Chemical Property of (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate

There total 8 articles about (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H17NO3S + pivaloyl chloride (3282-30-2) → (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate (1334209-45-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201103136

Reference yield:

4-(4-methyl-N-(prop-2-yn-1-yl)phenylsulfonamido)but-2-en-1-yl acetate (930607-96-8) → (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate (1334209-45-8)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol; potassium carbonate / 6 h / 20 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 0 - 20 °C / Inert atmosphere; Molecular sieve

3: tetrahydrofuran / 20 °C / Inert atmosphere

4: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With methanol; dmap; potassium carbonate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.201103136

Reference yield:

C14H15NO3S → (E)-6-(N-(prop-2-ynyl)-N-tosylamino)hex-4-en-1-yn-3-yl pivalate (1334209-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With dmap; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.201103136

upstream raw materials:

4-(4-methyl-N-(prop-2-yn-1-yl)phenylsulfonamido)but-2-en-1-yl acetate

C₁₄H₁₇NO₃S

4-methyl-N-prop-2-ynylbenzenesulfonamide

pivaloyl chloride

Downstream raw materials:

1,2,3,3a-tetrahydro-2-tosylcyclohepta[c]pyrrol-6-yl pivalate