4-((5-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)pentyl)amino)-4-oxobutanoic acid

Base Information

Chemical Name:4-((5-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)pentyl)amino)-4-oxobutanoic acid
CAS No.:1596369-09-3
Molecular Formula:C₂₂H₂₃F₃IN₃O₅
Molecular Weight:593.341
Hs Code.:

Synonyms:4-((5-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)pentyl)amino)-4-oxobutanoic acid

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Chemical Property of 4-((5-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)pentyl)amino)-4-oxobutanoic acid

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Technology Process of 4-((5-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)pentyl)amino)-4-oxobutanoic acid

There total 4 articles about 4-((5-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)pentyl)amino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-30-5
succinic acid anhydride

: 1596369-04-8
N-((5-aminopentyl)oxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

: 1596369-09-3
4-((5-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)pentyl)amino)-4-oxobutanoic acid

Guidance literature:: With pyridine; at 20 ℃; for 1h;
DOI:10.3390/molecules181113957

Reference yield:

: 1596368-97-6
C₁₈H₂₄N₂O₅

: 1596369-09-3
4-((5-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)pentyl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine / ethanol / 2 h / 20 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 10 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: pyridine / 1 h / 20 °C

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.3390/molecules181113957

Reference yield:

: 1596368-99-8
C₁₀H₂₂N₂O₃

: 1596369-09-3
4-((5-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)pentyl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 10 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: pyridine / 1 h / 20 °C

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.3390/molecules181113957