Technology Process of ethyl (S)-3-(4-(methyl(1-(((phenylmethyl)oxy)carbonyl)-2-methylpropyl)amino)-6,7-(1,2,3,4-tetrahydro-1,1,4,4-tetramethylbenzo)-1H-indol-3-yl)-2-oximidopropionate
There total 11 articles about ethyl (S)-3-(4-(methyl(1-(((phenylmethyl)oxy)carbonyl)-2-methylpropyl)amino)-6,7-(1,2,3,4-tetrahydro-1,1,4,4-tetramethylbenzo)-1H-indol-3-yl)-2-oximidopropionate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium carbonate;
In
dichloromethane;
for 12h;
DOI:10.1021/jo00015a026
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 99 percent / AlCl3 / 12 h / Heating
2: 57 percent / H2SO4, conc., HNO3, fum. / 1,2-dichloro-ethane / 2 h / 0 °C
3: 100 percent / Triton-B / dimethylsulfoxide / 12 h
4: 99 percent / cyclohexene / 10percent Pd/C / ethanol / 1 h / Heating
5: 95 percent / aq. NaHCO3 / tetrahydrofuran / 12 h / 0 deg C, warming to RT
6: 95 percent / Fe, HOAc / ethanol / 3 h / Heating
7: 78 percent / tris(triphenylphosphine)ruthenium dichloride / toluene / 3 h / Heating
8: 92 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating
9: 93 percent / 2,6-lutidine / 1,2-dichloro-ethane / 12 h / Heating
10: 50 percent / Na2CO3 / CH2Cl2 / 12 h
With
2,6-dimethylpyridine; lithium aluminium tetrahydride; aluminium trichloride; tris(triphenylphosphine)ruthenium(II) chloride; sulfuric acid; nitric acid; N-benzyl-trimethylammonium hydroxide; iron; sodium hydrogencarbonate; sodium carbonate; acetic acid; cyclohexene;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo00015a026
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 57 percent / H2SO4, conc., HNO3, fum. / 1,2-dichloro-ethane / 2 h / 0 °C
2: 100 percent / Triton-B / dimethylsulfoxide / 12 h
3: 99 percent / cyclohexene / 10percent Pd/C / ethanol / 1 h / Heating
4: 95 percent / aq. NaHCO3 / tetrahydrofuran / 12 h / 0 deg C, warming to RT
5: 95 percent / Fe, HOAc / ethanol / 3 h / Heating
6: 78 percent / tris(triphenylphosphine)ruthenium dichloride / toluene / 3 h / Heating
7: 92 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating
8: 93 percent / 2,6-lutidine / 1,2-dichloro-ethane / 12 h / Heating
9: 50 percent / Na2CO3 / CH2Cl2 / 12 h
With
2,6-dimethylpyridine; lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; sulfuric acid; nitric acid; N-benzyl-trimethylammonium hydroxide; iron; sodium hydrogencarbonate; sodium carbonate; acetic acid; cyclohexene;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo00015a026