Technology Process of (S)-4-(methyl(1-(((phenylmethyl)oxy)carbonyl)-2-methylpropyl)amino)-6,7-(1,2,3,4-tetrahydro-1,1,4,4-tetramethylbenzo)indole
There total 10 articles about (S)-4-(methyl(1-(((phenylmethyl)oxy)carbonyl)-2-methylpropyl)amino)-6,7-(1,2,3,4-tetrahydro-1,1,4,4-tetramethylbenzo)indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine;
In
1,2-dichloro-ethane;
for 12h;
Heating;
DOI:10.1021/jo00015a026
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 99 percent / AlCl3 / 12 h / Heating
2: 57 percent / H2SO4, conc., HNO3, fum. / 1,2-dichloro-ethane / 2 h / 0 °C
3: 100 percent / Triton-B / dimethylsulfoxide / 12 h
4: 99 percent / cyclohexene / 10percent Pd/C / ethanol / 1 h / Heating
5: 95 percent / aq. NaHCO3 / tetrahydrofuran / 12 h / 0 deg C, warming to RT
6: 95 percent / Fe, HOAc / ethanol / 3 h / Heating
7: 78 percent / tris(triphenylphosphine)ruthenium dichloride / toluene / 3 h / Heating
8: 92 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating
9: 93 percent / 2,6-lutidine / 1,2-dichloro-ethane / 12 h / Heating
With
2,6-dimethylpyridine; lithium aluminium tetrahydride; aluminium trichloride; tris(triphenylphosphine)ruthenium(II) chloride; sulfuric acid; nitric acid; N-benzyl-trimethylammonium hydroxide; iron; sodium hydrogencarbonate; acetic acid; cyclohexene;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo00015a026
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 57 percent / H2SO4, conc., HNO3, fum. / 1,2-dichloro-ethane / 2 h / 0 °C
2: 100 percent / Triton-B / dimethylsulfoxide / 12 h
3: 99 percent / cyclohexene / 10percent Pd/C / ethanol / 1 h / Heating
4: 95 percent / aq. NaHCO3 / tetrahydrofuran / 12 h / 0 deg C, warming to RT
5: 95 percent / Fe, HOAc / ethanol / 3 h / Heating
6: 78 percent / tris(triphenylphosphine)ruthenium dichloride / toluene / 3 h / Heating
7: 92 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating
8: 93 percent / 2,6-lutidine / 1,2-dichloro-ethane / 12 h / Heating
With
2,6-dimethylpyridine; lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; sulfuric acid; nitric acid; N-benzyl-trimethylammonium hydroxide; iron; sodium hydrogencarbonate; acetic acid; cyclohexene;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo00015a026
