Chemical Property of Cephaloridine
Chemical Property:
- Melting Point:184°C
- Refractive Index:1.6390 (estimate)
- PKA:3.2(at 25℃)
- PSA：146.96000
- Density:1.3230 (rough estimate)
- LogP:0.01100
- Storage Temp.:2-8°C
- Water Solubility.:>20g/L(21 oC)
- XLogP3:1.9
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:5
- Exact Mass:415.06604838
- Heavy Atom Count:28
- Complexity:687
- Purity/Quality:
-
99% *data from raw suppliers
Cephaloridine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
42/43
- Safety Statements:
22-36/37-45
- MSDS Files:
-
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1C(=C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=CC=C4
- Isomeric SMILES:C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=CC=C4
-
Description
This was derived by adding two side chains to the nucleus of
cephalothin, and has the formula 7-(2-thienyl acetamido)-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid betaine (Muggleton et al.,
1964). Cephaloridine was initially widely used, but it had two main
disadvantages. It was an unreliable antistaphylococcal drug, as it was
relatively easily hydrolyzed by Staphylococcus aureus beta-lactamase
(Laverdiere et al., 1978; Sabath, 1989). Second, cephaloridine was
nephrotoxic (Foord, 1975; Appel and Neu, 1977). Marketing of the
drug was discontinued in the USA in December 1980. Nowadays, this
drug is used very rarely, if at all.
-
Uses
Antibacterial agent.
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Therapeutic Function
Antibacterial
