(4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one

Base Information

• Chemical Name: (4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one
• CAS No.: 1100756-18-0
• Molecular Formula: C₁₆H₁₈N₂O₅S
• Molecular Weight: 350.395
• Mol file: 1100756-18-0.mol

Synonyms:(4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one

Chemical Property of (4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one

There total 3 articles about (4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide (1100756-19-1) → (4R,4aR)-2-[(2-aminophenyl)sulfonyl]-4,7-dimethyl-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-22-6) + (4R,4aS)-2-[(2-aminophenyl)sulfonyl]-4,7-dimethyl-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-24-8) + (4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-18-0)

Guidance literature:

With trimethylamine-N-oxide; In tetrahydrofuran; water; at 0 - 20 ℃; diastereoselective reaction;

DOI:10.1016/j.tet.2008.10.029

Reference yield: 33.0%

N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide (1100756-19-1) + carbon monoxide (201230-82-2) → (4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-18-0) + (4R,4aS)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-23-7)

Guidance literature:

With dicobalt octacarbonyl; In tetrachloromethane; at 77 ℃; for 24h; Molecular sieve;

DOI:10.1016/j.tet.2008.10.029

Reference yield: 32.0%

N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide (1100756-19-1) + carbon monoxide (201230-82-2) → (4R,4aR)-2-[(2-aminophenyl)sulfonyl]-4,7-dimethyl-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-22-6) + (4R,4aS)-2-[(2-aminophenyl)sulfonyl]-4,7-dimethyl-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-24-8) + (4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-18-0) + (4R,4aS)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-23-7)

Guidance literature:

With dicobalt octacarbonyl; In toluene; at 60 ℃; for 24h; diastereoselective reaction;

DOI:10.1016/j.tet.2008.10.029

upstream raw materials:

dicobalt octacarbonyl

N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide

carbon monoxide