N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide

Base Information

• Chemical Name: N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide
• CAS No.: 1100756-19-1
• Molecular Formula: C₁₅H₁₈N₂O₄S
• Molecular Weight: 322.385
• Mol file: 1100756-19-1.mol

Synonyms:N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide

Chemical Property of N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide

There total 1 articles about N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(but-2-yn-1-yl)-2-nitrobenzenesulfonamide (1100756-21-5) + (R)-2-methylbut-3-en-1-ol (22644-30-0) → N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide (1100756-19-1)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 12h;

DOI:10.1016/j.tet.2008.10.029

Reference yield: 71.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide (1100756-19-1) → (4R,4aR)-2-[(2-aminophenyl)sulfonyl]-4,7-dimethyl-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-22-6) + (4R,4aS)-2-[(2-aminophenyl)sulfonyl]-4,7-dimethyl-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-24-8) + (4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-18-0)

Guidance literature:

With trimethylamine-N-oxide; In tetrahydrofuran; water; at 0 - 20 ℃; diastereoselective reaction;

DOI:10.1016/j.tet.2008.10.029

Reference yield: 49.0%

N-but-2-yn-1-yl-N-[(2R)-2-methylbut-3-en-1-yl]-2-nitrobenzenesulfonamide (1100756-19-1) + carbon monoxide (201230-82-2) → (4R,4aR)-2-[(2-aminophenyl)sulfonyl]-4,7-dimethyl-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-22-6) + (4R,4aS)-2-[(2-aminophenyl)sulfonyl]-4,7-dimethyl-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one (1100756-24-8)

Guidance literature:

With dicobalt octacarbonyl; tert-butyl methyl sulphide; In 1,2-dichloro-ethane; at 83 ℃; for 3h; diastereoselective reaction;

DOI:10.1016/j.tet.2008.10.029

upstream raw materials:

N-(but-2-yn-1-yl)-2-nitrobenzenesulfonamide

(R)-2-methylbut-3-en-1-ol

Downstream raw materials:

(4R,4aR)-2-[(2-aminophenyl)sulfonyl]-4,7-dimethyl-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one

(4R,4aS)-2-[(2-aminophenyl)sulfonyl]-4,7-dimethyl-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one

(4R,4aR)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one

(4R,4aS)-4,7-dimethyl-2-[(2-nitrophenyl)sulfonyl]-1,2,3,4,4a,5-hexahydro-6H-cyclopenta[c]pyridin-6-one