L-Glutamic acid, N-L-alpha-glutamyl-

Base Information

• Chemical Name: L-Glutamic acid, N-L-alpha-glutamyl-
• CAS No.: 3929-61-1
• Molecular Formula: C10H16N2O7
• Molecular Weight: 276.246
• Hs Code.: 2924199090
• NSC Number: 335983
• DSSTox Substance ID: DTXSID70960026
• Mol file: 3929-61-1.mol

Synonyms:dipotassium glutamyl-glutamate;Glu-Glu;glutamyl-glutamic acid

Chemical Property of L-Glutamic acid, N-L-alpha-glutamyl-

Chemical Property:

• Vapor Pressure: 1.83E-19mmHg at 25°C
• Melting Point: 187℃ (Decomposition) (ethanol )
• Refractive Index: 1.553
• Boiling Point: 666 °C at 760 mmHg
• PKA: 2.97±0.10(Predicted)
• Flash Point: 356.6 °C
• PSA: 167.02000
• Density: 1.47 g/cm³
• LogP: -0.29610
• Storage Temp.: −20°C
• XLogP3: -5.1
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 276.09575085
• Heavy Atom Count: 19
• Complexity: 369

Purity/Quality:

98%min ^*data from raw suppliers

(S)-2-((S)-2-Amino-4-carboxybutanamido)pentanedioicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CC(=O)O)C(C(=O)NC(CCC(=O)O)C(=O)O)N

Technology Process of L-Glutamic acid, N-L-alpha-glutamyl-

There total 16 articles about L-Glutamic acid, N-L-alpha-glutamyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyloxycarbonyl-γ-benzyl-α-L-glutamyl-L-glutamic acid dibenzyl ester (6922-66-3) → L-glutamyl-L-glutamic acid (3929-61-1)

Guidance literature:

With hydrogen; palladium; In methanol; acetic acid; for 5h;

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + L-Lysine hydrochloride (657-27-2,10098-89-2,26124-78-7) → LysGluGlu (157535-07-4) + lysine tetrapeptide (997-20-6) + poly(L-lysine), 5-mer (19431-21-1) + Lys-Glu (45234-02-4) + L-glutamyl-L-glutamic acid (3929-61-1) + Lys-Lys-Lys (13184-14-0) + C11H19N3O4 (473452-81-2) + C16H24N4O6 + C22H36N6O7 + C27H41N7O9 + C28H48N8O8 + C32H46N8O11 + C33H53N9O10 + C34H60N10O9 + C33H55N9O11 + C38H58N10O12 + C38H58N10O12 + C39H65N11O11 + C44H70N12O13 + C49H75N13O15 + C55H87N15O16 + C50H82N14O14 + C49H75N13O15 + C44H70N12O13 + C39H65N11O11 + C38H58N10O12 + C38H58N10O12 + C33H53N9O10 + C32H46N8O11 + C27H41N7O9 + C21H29N5O8 + C16H24N4O6 + C11H19N3O4 + C55H87N15O16 + C54H80N14O17 + C49H75N13O15 + C44H70N12O13 + C39H65N11O11 + C38H58N10O12 + C38H58N10O12 + C35H67N11O8 + C33H53N9O10 + C33H55N9O11 + C28H48N8O8 + C32H46N8O11 + C27H41N7O9 + C22H36N6O7 + C17H31N5O5 + C50H82N14O14 + C40H72N12O10 + C44H70N12O13 + C39H65N11O11 + C34H60N10O9 + C29H55N9O7 + C23H43N7O6 + C36H44N8O14 + C31H39N7O12 + C26H34N6O10 + C21H29N5O8 + C20H24N4O10 + C15H19N3O8 + C10H14N2O6 (757898-70-7) + C39H69N11O13 + C33H57N9O12 + C32H50N8O13 + C32H48N8O12 + C27H45N7O11 + C28H50N8O9 + C27H43N7O10 + C22H38N6O8 + C17H33N5O6 (175175-64-1) + C17H33N5O6 (175176-04-2) + C34H62N10O10 + C39H67N11O12 + C40H74N12O11 + C45H79N13O13 + C46H86N14O12 + C45H81N13O14 + C33H57N9O12 + C38H62N10O14 + C43H67N11O16 + C44H74N12O15 + EKKK + EKKE (92172-18-4) + EKEE + KEKKK + EKKEK + EKEEK + KEKKKK (532436-32-1) + EKKEKK (927893-91-2) + EKEEKE (927894-29-9) + glu-Lys (5891-52-1,5891-53-2,130004-26-1)

Guidance literature:

With sulfuric acid; at 140 ℃; for 300h; Time; Temperature;

DOI:10.1007/s11172-012-0060-3

Reference yield:

glycolic Acid (79-14-1) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → Glu-Glu-Glu (23684-48-2) + L-glutamyl-L-glutamic acid (3929-61-1) + C12H18N2O9 + C7H11NO6

Guidance literature:

With tetraethylammonium chloride; In water; at 95 ℃; for 168h;

DOI:10.1039/d0cc03319g

upstream raw materials:

benzyloxycarbonyl-γ-benzyl-α-L-glutamyl-L-glutamic acid dibenzyl ester

N-(N-benzyloxycarbonyl-L-α-glutamyl)-glutamic acid

L-glutamic acid

N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid

Downstream raw materials:

L-glutamic acid

5-oxoprolyl-L-glutamic acid

Refernces

• 1、 Demina,Kononikhin,Laptev,Khodonov,Nikolaev,Varfolomeev. "Modelling of prebiotic synthesis and selection of peptides under isothermal conditions and thermal cycling mode". . p. 422 - 441. Retrieved 2013/06/27.
• 2、 Noda, Kosaku,Igata, Keiko,Horikawa, Yoshiko,Fujii, Hisao. "Synthesis of γ-Glutamyl Peptides Catalyzed by Transamidase from Bacillus natto". . p. 2419 - 2424. Retrieved 2007/10/02.