2,2-Dimethyl-propionic acid (R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propyl ester

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Chemical Name:2,2-Dimethyl-propionic acid (R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propyl ester
CAS No.:81479-08-5
Molecular Formula:C₃₄H₅₂O₅Si
Molecular Weight:568.869
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propyl ester

There total 17 articles about 2,2-Dimethyl-propionic acid (R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 81470-84-0
2,2-Dimethyl-propionic acid (2R,3R,4R,5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-2,4,6-trimethyl-heptyl ester

: 77-76-9
2,2-dimethoxy-propane

: 81479-08-5
2,2-Dimethyl-propionic acid (R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propyl ester

Guidance literature:: With camphor-10-sulfonic acid; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(01)93261-2

Reference yield:

: 81470-77-1,98102-72-8,100760-30-3,115181-74-3,133006-91-4,135211-99-3,138124-14-8,145514-09-6
(2S,3R,4R)-1-(benzyloxy)-3,5-(isopropylidenedioxy)-2,4-dimethylpentane

: 81479-08-5
2,2-Dimethyl-propionic acid (R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / liquid ammonia, Li / tetrahydrofuran / 0.33 h / Heating

2: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 0.25 h / -78 °C

3: 86 percent / chromic chloride, LAH / tetrahydrofuran / 0.5 h

5: 100 percent / AcOH / H₂O / 0.17 h / 40 °C

6: 92 percent / pyridine / CH₂Cl₂ / 0 deg C, 1.5 h. then room temp., 2 h.

7: 99 percent / camphorsulfonic acid / 2 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; camphor-10-sulfonic acid; ammonia; chromium(III) chloride; lithium; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4020(01)93261-2

Reference yield:

: 73814-75-2,73814-80-9,73837-43-1,79027-31-9,81520-04-9,81520-05-0,81520-08-3,81520-09-4,104320-78-7,115458-81-6,115458-82-7,125873-79-2,125873-80-5
[(2S,3S)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-oxiranyl]-methanol

: 81479-08-5
2,2-Dimethyl-propionic acid (R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 89 percent / copper (I) iodide / diethyl ether / -40 deg C, 5 h. then -23 deg C, 30 min.

2: 92 percent / camphorsulfonic acid / acetone / 0.5 h / 25 °C

3: 96 percent / liquid ammonia, Li / tetrahydrofuran / 0.33 h / Heating

4: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 0.25 h / -78 °C

5: 86 percent / chromic chloride, LAH / tetrahydrofuran / 0.5 h

7: 100 percent / AcOH / H₂O / 0.17 h / 40 °C

8: 92 percent / pyridine / CH₂Cl₂ / 0 deg C, 1.5 h. then room temp., 2 h.

9: 99 percent / camphorsulfonic acid / 2 h / Ambient temperature

With pyridine; copper(l) iodide; lithium aluminium tetrahydride; oxalyl dichloride; camphor-10-sulfonic acid; ammonia; chromium(III) chloride; lithium; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(01)93261-2