3-(4-Bromo-phenyl)-2-((E)-3-oxo-3-p-tolyl-propenyl)-3H-quinazolin-4-one

Base Information

• Chemical Name: 3-(4-Bromo-phenyl)-2-((E)-3-oxo-3-p-tolyl-propenyl)-3H-quinazolin-4-one
• CAS No.: 128457-99-8
• Molecular Formula: C₂₄H₁₇BrN₂O₂
• Molecular Weight: 445.315

Synonyms:3-(4-Bromo-phenyl)-2-((E)-3-oxo-3-p-tolyl-propenyl)-3H-quinazolin-4-one

Chemical Property of 3-(4-Bromo-phenyl)-2-((E)-3-oxo-3-p-tolyl-propenyl)-3H-quinazolin-4-one

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Technology Process of 3-(4-Bromo-phenyl)-2-((E)-3-oxo-3-p-tolyl-propenyl)-3H-quinazolin-4-one

There total 1 articles about 3-(4-Bromo-phenyl)-2-((E)-3-oxo-3-p-tolyl-propenyl)-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-methylphenylglyoxal (1075-47-4) + 3-(4-bromophenyl)-2-methylquinazolin-4(3H)-one (1788-95-0) → 3-(4-Bromo-phenyl)-2-((E)-3-oxo-3-p-tolyl-propenyl)-3H-quinazolin-4-one (128457-99-8)

Guidance literature:

In acetic anhydride; for 0.25h; Heating;

DOI:10.1002/ardp.19903230511

Reference yield: 85.0%

3-(4-Bromo-phenyl)-2-((E)-3-oxo-3-p-tolyl-propenyl)-3H-quinazolin-4-one (128457-99-8) + thiosemicarbazide (79-19-6) → 5-[3-(4-Bromo-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-3-p-tolyl-pyrazole-1-carbothioic acid amide

Guidance literature:

In acetic acid; for 8h; Heating;

DOI:10.1002/ardp.19943270105

Reference yield: 83.0%

3-(4-Bromo-phenyl)-2-((E)-3-oxo-3-p-tolyl-propenyl)-3H-quinazolin-4-one (128457-99-8) + aminoguanidine (79-17-4) → 5-[3-(4-Bromo-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-3-p-tolyl-pyrazole-1-carboxamidine

Guidance literature:

In ethanol; acetic acid; for 6h; Heating;

DOI:10.1002/ardp.19943270105

upstream raw materials:

4-methylphenylglyoxal

3-(4-bromophenyl)-2-methylquinazolin-4(3H)-one

Downstream raw materials:

3-(4-Bromo-phenyl)-2-(2,5-di-p-tolyl-2H-pyrazol-3-yl)-3H-quinazolin-4-one

3-(4-Bromo-phenyl)-2-[2-(4-bromo-phenyl)-5-p-tolyl-2H-pyrazol-3-yl]-3H-quinazolin-4-one

3-(4-Bromo-phenyl)-2-(2-phenyl-5-p-tolyl-2H-pyrazol-3-yl)-3H-quinazolin-4-one

3-(4-Bromo-phenyl)-2-(5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-3H-quinazolin-4-one

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