methyl 4-[(2,2-dimethylpropanoyl)amino]-2-(2-propyn-1-yloxy)benzoate

Base Information

• Chemical Name: methyl 4-[(2,2-dimethylpropanoyl)amino]-2-(2-propyn-1-yloxy)benzoate
• CAS No.: 180630-37-9
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.331
• Mol file: 180630-37-9.mol

Synonyms:methyl 4-[(2,2-dimethylpropanoyl)amino]-2-(2-propyn-1-yloxy)benzoate

Chemical Property of methyl 4-[(2,2-dimethylpropanoyl)amino]-2-(2-propyn-1-yloxy)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-[(2,2-dimethylpropanoyl)amino]-2-(2-propyn-1-yloxy)benzoate

There total 3 articles about methyl 4-[(2,2-dimethylpropanoyl)amino]-2-(2-propyn-1-yloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

propargyl bromide (106-96-7) + methyl 4-[(2,2-dimethylpropanoyl)amino]-2-hydroxybenzoate (180630-43-7) → methyl 4-[(2,2-dimethylpropanoyl)amino]-2-(2-propyn-1-yloxy)benzoate (180630-37-9)

Guidance literature:

With potassium carbonate; In acetone; for 20h; Reflux;

DOI:10.1021/op900188v

Reference yield:

pivaloyl chloride (3282-30-2) → methyl 4-[(2,2-dimethylpropanoyl)amino]-2-(2-propyn-1-yloxy)benzoate (180630-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.6 percent / triethylamine / CH₂Cl₂ / 3 h / 20 °C

2: 89.6 percent / potassium carbonate / dimethylformamide / 4 h / 70 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.3987/COM-98-8294

Reference yield:

methyl 4-aminosalicylate (4136-97-4) → methyl 4-[(2,2-dimethylpropanoyl)amino]-2-(2-propyn-1-yloxy)benzoate (180630-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.6 percent / triethylamine / CH₂Cl₂ / 3 h / 20 °C

2: 89.6 percent / potassium carbonate / dimethylformamide / 4 h / 70 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.3987/COM-98-8294

upstream raw materials:

propargyl bromide

methyl 4-[(2,2-dimethylpropanoyl)amino]-2-hydroxybenzoate

pivaloyl chloride

methyl 4-aminosalicylate

Downstream raw materials:

C₁₆H₂₁NO₅

methyl 4-[(2,2-dimethylpropanoyl)amino]-2-hydroxybenzoate

methyl 5-chloro-4-pivaloylamino-2-propargyloxybenzoate