2-(2-METHOXYPHENOXY)ANILINE

Base Information

• Chemical Name: 2-(2-METHOXYPHENOXY)ANILINE
• CAS No.: 22751-09-3
• Molecular Formula: C13H13 N O2
• Molecular Weight: 215.252
• Hs Code.: 2922299090
• Mol file: 22751-09-3.mol

Synonyms:Aniline,o-(o-methoxyphenoxy)- (6CI,7CI,8CI); 2-Aminophenyl 2-methoxyphenyl ether; NSC77973

Chemical Property of 2-(2-METHOXYPHENOXY)ANILINE

Chemical Property:

• Vapor Pressure: 0.000242mmHg at 25°C
• Melting Point: 67-68 °C
• Boiling Point: 324.6°C at 760 mmHg
• PKA: 4.02±0.10(Predicted)
• Flash Point: 164.2°C
• PSA: 44.48000
• Density: 1.155g/cm³
• LogP: 3.65090
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Methoxyphenoxy)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-METHOXYPHENOXY)ANILINE

There total 5 articles about 2-(2-METHOXYPHENOXY)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-methoxy-2-(2-nitrophenoxy)benzene (74865-12-6) → 2-amino-2'-methoxydiphenyl ether (22751-09-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jm030957n

Reference yield:

2-methoxy-phenol (90-05-1) → 2-amino-2'-methoxydiphenyl ether (22751-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / NaH; CuBr*SMe₂ / dimethylformamide / 3 h / Heating

2: 94 percent / H₂ / Pd/C / methanol / 3 h / 20 °C

With copper(I) bromide dimethylsulfide complex; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1: Ullmann reaction;

DOI:10.1021/jm030957n

Reference yield:

2-nitrophenyl bromide (577-19-5) → 2-amino-2'-methoxydiphenyl ether (22751-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / NaH; CuBr*SMe₂ / dimethylformamide / 3 h / Heating

2: 94 percent / H₂ / Pd/C / methanol / 3 h / 20 °C

With copper(I) bromide dimethylsulfide complex; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1: Ullmann reaction;

DOI:10.1021/jm030957n

upstream raw materials:

1-methoxy-2-(2-nitrophenoxy)benzene

2-nitrophenyl bromide

2-methoxy-phenol

ortho-nitrofluorobenzene

Refernces

• 1、 Tietze, Lutz F.,Waldecker, Bernd,Ganapathy, Dhandapani,Eichhorst, Christoph,Lenzer, Thomas,Oum, Kawon,Reichmann, Sven O.,Stalke, Dietmar. "Four- and Sixfold Tandem-Domino Reactions Leading to Dimeric Tetrasubstituted Alkenes Suitable as Molecular Switches". . p. 10317 - 10323. Retrieved 2015/09/01.
• 2、 De La Fuente, Jesús ángel,Manzanaro, Sonia,Martín, María Jesús,De Quesada, Teresa G.,Reymundo, Isabel,Luengo, Santos M.,Gago, Federico. "Synthesis, Activity, and Molecular Modeling Studies of Novel Human Aldose Reductase Inhibitors Based on a Marine Natural Product". . p. 5208 - 5221. Retrieved 2007/10/03.