(1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:158818-65-6
Molecular Formula:C₁₈H₂₈O₄
Molecular Weight:308.418
Hs Code.:

Synonyms:(1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Chemical Property of (1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of (1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 3 articles about (1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 623-43-8,4358-59-2,18707-60-3,130981-57-6
methyl crotonate

: 59557-05-0
(L)-menthyl 3-oxobutyrate

: 158818-65-6
(1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: (1S,2R)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol;
DOI:10.1021/ja00104a041

Reference yield: 25.0%

: 623-70-1
ethyl (E)-crotonate

: 59557-05-0
(L)-menthyl 3-oxobutyrate

: 158818-65-6
(1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: (1S,2R)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; reflux, 2.5 h, rt;
DOI:10.1021/ja9703741

Reference yield:

: 2216-51-5
(-)-menthol

: 158818-65-6
(1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / toluene / 26 h / Heating

2: 36 percent / KOt-Bu / 2-methyl-propan-2-ol / reflux, 2.5 h, rt

With potassium tert-butylate; In toluene; tert-butyl alcohol;
DOI:10.1021/ja9703741