(1R,6S)-4-Methoxy-6-methyl-2-oxo-cyclohex-3-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(1R,6S)-4-Methoxy-6-methyl-2-oxo-cyclohex-3-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:158818-66-7
Molecular Formula:C₁₉H₃₀O₄
Molecular Weight:322.445
Hs Code.:

Synonyms:(1R,6S)-4-Methoxy-6-methyl-2-oxo-cyclohex-3-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Suppliers and Price of (1R,6S)-4-Methoxy-6-methyl-2-oxo-cyclohex-3-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,6S)-4-Methoxy-6-methyl-2-oxo-cyclohex-3-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,6S)-4-Methoxy-6-methyl-2-oxo-cyclohex-3-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 5 articles about (1R,6S)-4-Methoxy-6-methyl-2-oxo-cyclohex-3-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 67-56-1
methanol

: 158818-65-6
(1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: 158818-66-7
(1R,6S)-4-Methoxy-6-methyl-2-oxo-cyclohex-3-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: (1R,6S)-2-Methoxy-6-methyl-4-oxo-cyclohex-2-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: With camphor-10-sulfonic acid; at 23 ℃; for 12h; Yields of byproduct given;
DOI:10.1021/ja9703741

Reference yield: 71.0%

: 67-56-1
methanol

: 158818-65-6
(1R,2S)-2-Methyl-4,6-dioxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: 158818-66-7
(1R,6S)-4-Methoxy-6-methyl-2-oxo-cyclohex-3-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: With camphor-10-sulfonic acid;
DOI:10.1021/ja00104a041

Reference yield:

: 2216-51-5
(-)-menthol

: 158818-66-7
(1R,6S)-4-Methoxy-6-methyl-2-oxo-cyclohex-3-enecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / toluene / 26 h / Heating

2: 36 percent / KOt-Bu / 2-methyl-propan-2-ol / reflux, 2.5 h, rt

3: 71 percent / camphorsulfonic acid / 12 h / 23 °C

With camphor-10-sulfonic acid; potassium tert-butylate; In toluene; tert-butyl alcohol;
DOI:10.1021/ja9703741