6-(p-chlorophenyl)-2-(1H-indole-3-yl)-4-(p-methoxyphenyl)nicotinonitrile

Base Information

Chemical Name:6-(p-chlorophenyl)-2-(1H-indole-3-yl)-4-(p-methoxyphenyl)nicotinonitrile
CAS No.:1415404-09-9
Molecular Formula:C₂₇H₁₈ClN₃O
Molecular Weight:435.912
Hs Code.:

Synonyms:6-(p-chlorophenyl)-2-(1H-indole-3-yl)-4-(p-methoxyphenyl)nicotinonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(p-chlorophenyl)-2-(1H-indole-3-yl)-4-(p-methoxyphenyl)nicotinonitrile

Chemical Property:

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Technology Process of 6-(p-chlorophenyl)-2-(1H-indole-3-yl)-4-(p-methoxyphenyl)nicotinonitrile

There total 4 articles about 6-(p-chlorophenyl)-2-(1H-indole-3-yl)-4-(p-methoxyphenyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 99-91-2
para-chloroacetophenone

: 123-11-5
4-methoxy-benzaldehyde

: 20356-45-0
3-(1H-indol-3-yl)-3-oxo-propionitrile

: 1415404-09-9
6-(p-chlorophenyl)-2-(1H-indole-3-yl)-4-(p-methoxyphenyl)nicotinonitrile

Guidance literature:: With ammonium acetate; iodine; In acetic acid; for 6h; Reflux;
DOI:10.1080/00397911.2011.607933

Reference yield: 69.0%

: 1012997-19-1
C₁₉H₁₄N₂O₂

: 99-91-2
para-chloroacetophenone

: 1415404-09-9
6-(p-chlorophenyl)-2-(1H-indole-3-yl)-4-(p-methoxyphenyl)nicotinonitrile

Guidance literature:: With ammonium acetate; iodine; acetic acid; at 120 ℃;
DOI:10.1016/j.bioorg.2020.103673

Reference yield:

: 20356-45-0
3-(1H-indol-3-yl)-3-oxo-propionitrile

: 1415404-09-9
6-(p-chlorophenyl)-2-(1H-indole-3-yl)-4-(p-methoxyphenyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / Reflux

2: ammonium acetate; iodine; acetic acid / 120 °C

With ammonium acetate; iodine; acetic acid; triethylamine; In ethanol;
DOI:10.1016/j.bioorg.2020.103673