1-(2-((2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

Base Information

Chemical Name:1-(2-((2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide
CAS No.:1566544-40-8
Molecular Formula:C₂₃H₁₈F₃N₅O₂
Molecular Weight:453.423
Hs Code.:

Synonyms:1-(2-((2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

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Chemical Property of 1-(2-((2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(2-((2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

There total 3 articles about 1-(2-((2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1566544-35-1
4-chloro-N-(6-methoxypyridin-3-yl)-5-(trifluoromethyl)pyrimidin-2-amine

: 1566543-59-6
1-(2-ethynyl phenyl)cyclopropanecarboxamide

: 1566544-40-8
1-(2-((2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

Guidance literature:: 4-chloro-N-(6-methoxypyridin-3-yl)-5-(trifluoromethyl)pyrimidin-2-amine; 1-(2-ethynyl phenyl)cyclopropanecarboxamide; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

With triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 6628-77-9
6-methoxy-pyridin-3-ylamine

: 1566544-40-8
1-(2-((2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc(II) chloride; triethylamine / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

2.2: 0.25 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1566544-40-8
1-(2-((2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc(II) chloride; triethylamine / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

2.2: 0.25 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;