1-(2-(2-(2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Chemical Name:1-(2-(2-(2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide
CAS No.:1566543-39-2
Molecular Formula:C₂₃H₂₂F₃N₅O₂
Molecular Weight:457.455
Hs Code.:

Synonyms:1-(2-(2-(2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Chemical Property of 1-(2-(2-(2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Technology Process of 1-(2-(2-(2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

There total 4 articles about 1-(2-(2-(2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1566544-40-8
1-(2-((2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

: 1566543-39-2
1-(2-(2-(2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 32h;

Reference yield:

: 1566544-35-1
4-chloro-N-(6-methoxypyridin-3-yl)-5-(trifluoromethyl)pyrimidin-2-amine

: 1566543-39-2
1-(2-(2-(2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

1.2: 0.25 h / 120 °C / Microwave irradiation

2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 32 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 6628-77-9
6-methoxy-pyridin-3-ylamine

: 1566543-39-2
1-(2-(2-(2-((6-methoxypyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc(II) chloride; triethylamine / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

2.2: 0.25 h / 120 °C / Microwave irradiation

3.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 32 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; triethylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; zinc(II) chloride; In diethyl ether; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;