5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)-aminoprop-1-yl-6-N-benzoyladenosine

Base Information

• Chemical Name: 5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)-aminoprop-1-yl-6-N-benzoyladenosine
• CAS No.: 1454711-19-3
• Molecular Formula: C₅₆H₅₂N₆O₉
• Molecular Weight: 953.064
• Mol file: 1454711-19-3.mol

Synonyms:5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)-aminoprop-1-yl-6-N-benzoyladenosine

Chemical Property of 5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)-aminoprop-1-yl-6-N-benzoyladenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)-aminoprop-1-yl-6-N-benzoyladenosine

There total 2 articles about 5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)-aminoprop-1-yl-6-N-benzoyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C41H42N6O7 + C15H12O6S → 5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)-aminoprop-1-yl-6-N-benzoyladenosine (1454711-19-3)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.3390/molecules18077346

Reference yield:

5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-azidoprop-1-yl-6-N-benzoyladenosine (1005190-89-5) → 5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)-aminoprop-1-yl-6-N-benzoyladenosine (1454711-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylphosphane / tetrahydrofuran; water / 8 h / 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / water; 1,4-dioxane / 0.25 h / 0 °C / Inert atmosphere

With sodium hydrogencarbonate; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.3390/molecules18077346

Reference yield: 90.0%

5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)-aminoprop-1-yl-6-N-benzoyladenosine (1454711-19-3) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) (1454711-20-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.3390/molecules18077346

upstream raw materials:

5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-azidoprop-1-yl-6-N-benzoyladenosine

Downstream raw materials:

5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)