5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Base Information

Chemical Name:5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)
CAS No.:1454711-20-6
Molecular Formula:C₆₅H₆₉N₈O₁₀P
Molecular Weight:1153.28
Hs Code.:

5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Synonyms:5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

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Chemical Property of 5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

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Technology Process of 5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

There total 3 articles about 5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1454711-19-3
5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)-aminoprop-1-yl-6-N-benzoyladenosine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1454711-20-6
5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.3390/molecules18077346

Reference yield:

: 1005190-89-5
5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-azidoprop-1-yl-6-N-benzoyladenosine

: 1454711-20-6
5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylphosphane / tetrahydrofuran; water / 8 h / 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / water; 1,4-dioxane / 0.25 h / 0 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.3390/molecules18077346

Reference yield:

: C₄₁H₄₂N₆O₇

: 1454711-20-6
5′-O-(4,4′-dimethoxytriphenylmethyl)-2′-O-(9H-fluoren-9-yl-methylcarbonyl)aminoprop-1-yl-6-Nbenzoyladenosine-3′-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water; 1,4-dioxane / 0.25 h / 0 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.3390/molecules18077346