4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

Base Information

Chemical Name:4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid
CAS No.:1562193-96-7
Molecular Formula:C₂₄H₁₇ClF₂N₂O₃
Molecular Weight:454.86
Hs Code.:

Synonyms:4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

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Chemical Property of 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

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Technology Process of 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

There total 12 articles about 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.2%

: 1562195-14-5
4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid

: 1562193-96-7
4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

Guidance literature:: With boron tribromide; In dichloromethane; at -70 ℃; for 2h;

Reference yield:

: 1562195-11-2
methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

: 1562193-96-7
4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 16 h / 10 °C

2: boron tribromide / dichloromethane / 2 h / -70 °C

With water; boron tribromide; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 64622-16-8
2-bromo-6-chlorobenzaldehyde

: 1562193-96-7
4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; water / 16 h / 100 °C / Inert atmosphere

2: potassium borohydride / methanol / 2 h / 0 °C

3: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 4 h / 10 °C

4: caesium carbonate / N,N-dimethyl-formamide / 2 h / 10 °C

5: water; lithium hydroxide / tetrahydrofuran / 16 h / 10 °C

6: boron tribromide / dichloromethane / 2 h / -70 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; potassium borohydride; water; boron tribromide; caesium carbonate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;