4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid

Base Information

Chemical Name:4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid
CAS No.:1562195-14-5
Molecular Formula:C₂₅H₁₉ClF₂N₂O₃
Molecular Weight:468.887
Hs Code.:

Synonyms:4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid

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Chemical Property of 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid

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Technology Process of 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid

There total 11 articles about 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1562195-11-2
methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

: 1562195-14-5
4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 10 ℃; for 16h;

Reference yield:

: 1268862-74-3
2-chloro-6-cyclopropylbenzaldehyde

: 1562195-14-5
4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium borohydride / methanol / 2 h / 0 °C

2: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 4 h / 10 °C

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 10 °C

4: water; lithium hydroxide / tetrahydrofuran / 16 h / 10 °C

With N-Bromosuccinimide; potassium borohydride; water; caesium carbonate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1268866-25-6
(2-chloro-6-cyclopropylphenyl)methanol

: 1562195-14-5
4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 4 h / 10 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 10 °C

3: water; lithium hydroxide / tetrahydrofuran / 16 h / 10 °C

With N-Bromosuccinimide; water; caesium carbonate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;