methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

Base Information

Chemical Name:methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate
CAS No.:1562195-11-2
Molecular Formula:C₂₆H₂₁ClF₂N₂O₃
Molecular Weight:482.914
Hs Code.:

Synonyms:methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

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Chemical Property of methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

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Technology Process of methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

There total 10 articles about methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1562194-43-7
2-(bromomethyl)-1-chloro-3-cyclopropylbenzene

: 1562195-11-2
methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 10 ℃; for 2h;

Reference yield: 41.0%

: 1562194-37-9
methyl 5-fluoro-4-(4-fluoro-1H-indazol-3-yl)-2-methoxybenzoate

: 1562194-43-7
2-(bromomethyl)-1-chloro-3-cyclopropylbenzene

: 1562195-11-2
methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 10 ℃; for 2h;

Reference yield:

: 1268866-25-6
(2-chloro-6-cyclopropylphenyl)methanol

: 1562195-11-2
methyl 4-(1-(2-chloro-6-cyclopropylbenzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 4 h / 10 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 10 °C

With N-Bromosuccinimide; caesium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;